What are the potential pitfalls of mixing HTML output with PHP processing in a web application?

Mixing HTML output with PHP processing can make the code difficult to read and maintain, as it can lead to a tangled mess of logic and presentation. It can also make it harder to debug and test the code, as it becomes harder to isolate and troubleshoot issues. To solve this issue, it's best to separate the PHP processing logic from the HTML output by using a template engine like Twig or Blade.

<?php
// Separate PHP processing from HTML output using a template engine like Twig

require_once 'vendor/autoload.php';

$loader = new \Twig\Loader\FilesystemLoader('templates');
$twig = new \Twig\Environment($loader);

$data = [
    'title' => 'Hello, World!',
    'content' => 'This is a sample content',
];

echo $twig->render('index.html', $data);
?>