How does the order of operations in a PHP script affect the setting and handling of cookies?

The order of operations in a PHP script is crucial when setting and handling cookies. Cookies must be set before any output is sent to the browser, as headers, including the Set-Cookie header, must be sent before any content. Therefore, make sure to set cookies at the beginning of the script before any HTML or text output.

<?php
// Set cookies before any output
setcookie("username", "John Doe", time() + 3600, "/");
setcookie("user_id", 12345, time() + 3600, "/");

// Rest of the PHP script
?>