How can PHP variables be properly utilized in button onClick functions for data manipulation?

When using PHP variables in button onClick functions for data manipulation, it is important to remember that PHP is a server-side language and cannot directly interact with client-side events like button clicks. To utilize PHP variables in button onClick functions, you can use AJAX to send the variables to a PHP script on the server, perform the necessary data manipulation, and then return the result back to the client-side for display.

<button onclick="getData()">Get Data</button>

<script>
function getData() {
    var phpVariable = "<?php echo $phpVariable; ?>";

    // Use AJAX to send phpVariable to a PHP script on the server for data manipulation
    // Display the result back on the client-side
}
</script>