How can PHP scripts be structured to handle multiple function calls effectively?

To handle multiple function calls effectively in PHP scripts, you can organize your functions into separate files and then include them as needed using the `require_once` or `include_once` functions. This helps keep your code modular and easier to maintain. Additionally, you can create classes and use object-oriented programming principles to encapsulate related functions and data.

// functions.php
function foo() {
    // function logic here
}

function bar() {
    // function logic here
}

// index.php
require_once 'functions.php';

foo();
bar();