How can PHP interact with HTML and JavaScript to achieve dynamic content loading on user interaction?

To achieve dynamic content loading on user interaction, PHP can interact with HTML and JavaScript by using AJAX (Asynchronous JavaScript and XML). This allows the browser to send asynchronous requests to the server, retrieve data from PHP scripts, and update the HTML content dynamically without reloading the entire page.

```php
// PHP script to handle AJAX request
if(isset($_GET['data'])){
    $data = $_GET['data'];
    
    // Process the data as needed
    $result = "Processed data: " . $data;
    
    // Return the result as JSON
    echo json_encode($result);
    exit;
}
```

This PHP script can be called using JavaScript in the HTML file to send AJAX requests, retrieve the processed data, and update the content dynamically based on user interaction.