How can PHP functions be designed to manipulate variables without the need for reassignment?

To manipulate variables without the need for reassignment in PHP functions, you can pass variables by reference using the `&` symbol before the variable name in the function parameter list. This allows the function to directly modify the original variable rather than creating a copy.

function manipulateVariable(&$var) {
    $var = $var * 2;
}

$num = 5;
manipulateVariable($num);
echo $num; // Output: 10