How can PHP developers ensure that their code is secure and optimized when interacting with a MySQL database?

To ensure that PHP code interacting with a MySQL database is secure and optimized, developers should use parameterized queries to prevent SQL injection attacks and optimize database queries by only selecting the necessary data. Additionally, developers should properly handle errors and exceptions to improve code reliability.

// Example of using parameterized queries to prevent SQL injection
$stmt = $pdo->prepare('SELECT * FROM users WHERE username = :username');
$stmt->bindParam(':username', $username);
$stmt->execute();
```
```php
// Example of optimizing database queries by selecting only necessary data
$stmt = $pdo->query('SELECT id, username FROM users');
while ($row = $stmt->fetch()) {
    // Process data
}
```
```php
// Example of handling errors and exceptions
try {
    $pdo = new PDO('mysql:host=localhost;dbname=mydatabase', 'username', 'password');
} catch (PDOException $e) {
    echo 'Connection failed: ' . $e->getMessage();
}