How can PHP developers effectively handle spam prevention in guestbooks or form submissions?

Spam prevention in guestbooks or form submissions can be effectively handled by implementing CAPTCHA verification. This requires users to complete a challenge (such as typing distorted text) before their submission is accepted, thus reducing automated spam submissions.

```php
// PHP code snippet for implementing CAPTCHA verification in a form submission

session_start();

if ($_SERVER["REQUEST_METHOD"] == "POST") {
    if ($_POST["captcha"] == $_SESSION["captcha"]) {
        // CAPTCHA verification passed, process form submission
        // Insert code to handle form submission here
    } else {
        // CAPTCHA verification failed, display error message
        echo "CAPTCHA verification failed. Please try again.";
    }
}

// Generate random CAPTCHA code and store it in session
$randomCaptcha = substr(str_shuffle("abcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZ0123456789"), 0, 6);
$_SESSION["captcha"] = $randomCaptcha;

// Display CAPTCHA image in the form
echo '<img src="captcha_image.php" alt="CAPTCHA Image">';
echo '<input type="text" name="captcha" placeholder="Enter CAPTCHA code">';
```
This code snippet demonstrates how to implement CAPTCHA verification in a form submission using PHP. It generates a random CAPTCHA code, stores it in the session, and displays the CAPTCHA image in the form. Upon form submission, the code checks if the entered CAPTCHA matches the stored value before processing the submission. If the verification fails, an error message is displayed.