How can PHP be used to calculate the time difference between two dates?

To calculate the time difference between two dates in PHP, you can use the `DateTime` class to create two `DateTime` objects representing the two dates. Then, you can use the `diff()` method to calculate the difference between the two dates.

$date1 = new DateTime('2022-01-01');
$date2 = new DateTime('2022-01-10');

$interval = $date1->diff($date2);

echo $interval->format('%R%a days');