How can one ensure the successful transmission and manipulation of variables between PHP and JavaScript in a web application?

To ensure successful transmission and manipulation of variables between PHP and JavaScript in a web application, you can use AJAX to send data from PHP to JavaScript asynchronously. This allows for real-time updates without refreshing the page. You can encode PHP variables into JSON format before sending them to JavaScript for easy manipulation.

<?php
// PHP code to encode variables into JSON format
$variable1 = "Hello";
$variable2 = "World";
$data = array('var1' => $variable1, 'var2' => $variable2);
echo json_encode($data);
?>