How can developers ensure that the query and variables are sent separately to the database for security and prevention of SQL injection when using prepared statements in PHP?

To ensure that the query and variables are sent separately to the database for security and prevention of SQL injection when using prepared statements in PHP, developers should use placeholders in the query and bind the variables separately. This way, the variables are never directly inserted into the query string, reducing the risk of SQL injection attacks.

// Example of using prepared statements with placeholders and binding variables separately
$stmt = $pdo->prepare("SELECT * FROM users WHERE username = :username");
$stmt->bindParam(':username', $username);
$stmt->execute();