How can CSS and HTML be optimized to ensure compatibility with different browsers, including Chrome?

To ensure compatibility with different browsers, including Chrome, CSS and HTML can be optimized by using vendor prefixes, avoiding browser-specific hacks, and testing the website on different browsers regularly. Additionally, using modern CSS techniques like flexbox and grid layouts can help ensure better cross-browser compatibility. ```html <!DOCTYPE html> <html> <head> <style> .box { display: -webkit-box; /* Chrome, Safari, iOS and Android */ display: -ms-flexbox; /* IE 10 */ display: flex; } </style> </head> <body> <div class="box"> <div>Box 1</div> <div>Box 2</div> <div>Box 3</div> </div> </body> </html> ```