Are there any security concerns when using placeholders and variable replacement in PHP strings?

When using placeholders and variable replacement in PHP strings, there is a security concern known as SQL injection if user input is directly inserted into the query without proper sanitization. To prevent this, it is important to use prepared statements with placeholders for variables in SQL queries to ensure that user input is properly escaped and sanitized.

// Using prepared statements to prevent SQL injection
$pdo = new PDO("mysql:host=localhost;dbname=mydatabase", "username", "password");

$stmt = $pdo->prepare("SELECT * FROM users WHERE username = :username");
$stmt->bindParam(':username', $username, PDO::PARAM_STR);
$stmt->execute();

// Fetch data from the query result
$result = $stmt->fetch();